2024

1.     Sano M, Yamaji H, Higashiya S, Kubo M, Murakami T, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S. Efficacy and safety of a novel temperature-controlled catheter for cavotricuspid isthmus ablation. J Cardiovascular Electrophysiology 2024. https://doi.org/10.1111/jce.16378

2.     Fujii M, Kakimoto M, Sato I, Honma K, Kirihara S, Nakayama H, Fukuoka T, Hirohata S, Kitamori K, Ran S, Yamamoto S, Watanabe S. Uric Acid Elevation by Fructose Overload Exacerbates Nash and Atherosclerosis via Oxidative Stress. Current Nutrition and Food Science 2024. 20(2), 250-261 doi:10.2174/1573401319666230508150159

3.     Honma K, Kirihara S, Nakayama H, Fukuoka T, Ohara T, Kitamori K, Sato I, Hirohata S, Fujii M, Yamamoto S, Ran S, Watanabe S. Selective autophagy associated with iron overload aggravates non-alcoholic steatohepatitis via ferroptosis. Exp Biol Med (IF: 2.69; Q3)　doi: 10.1177/15353702231191197.

4.     Nishimura　S, Tanaka R, Kamikawa S, Waki1 I, Yamashita D, Tabita N, Higashiya S, Yamaji H, Murakami T, Kusachi S. Borg’s exertion scale did not coincide with ventilatory anaerobic threshold in atrial fibrillation patients with restored sinus rhythm after ablation. Journal of Exercise Rehabilitation 2024; 20(2): 83-90.

5.     Sakanoue H, Yamaji H,　Okamoto S, Kumi O, Fujita Y, Higashiya S, Murakami T, Kusachi S. Incidence of nausea/vomiting following propofol sedation with adaptive servo- ventilation for atrial fibrillation ablation. J Arhhythmia 2024

2023       

6.     Akagi S, Nakamura K, Kondo M, Hirohata S, Udono H, Nishida M, Saito Y, Yoshida M, Miyoshi T, Ito H. Evidence for Hypoxia-Induced Shift in ATP Production from Glycolysis to Mitochondrial Respiration in Pulmonary Artery Smooth Muscle Cells in Pulmonary Arterial Hypertension. J. Clin Med.  (IF: 3.9; Q2) 2023; 12(15):5028. https://doi.org/10.3390/jcm12155028

7.     Kakimoto M, Fujii M, Sato I, Honma K, Nakayama H, Kirihara S, Fukuoka T, Ran S, Hirohata S, Kitamori K, Yamamoto S, Watanabe S. Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats. J Appl Biomed (IF: 1.8; Q4). 2023;21(2):80-90. doi: 10.32725/jab.2023.009.

8.     Yamamoto S, Sato I, Fujii M, Kakimoto M, Honma K, Kirihara S, Nakayama H, Fukuoka T, Tamura S, Ueda M, Hirohata S, Watanabe S. Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model. Can J Physiol Pharmacol (IF: 2.27; Q4). 2023;101(9):455-465. doi: 10.1139/cjpp-2022-0532.

9.        Yamamoto S, Honma K, Fujii M, Kakimoto M, Kirihara S, Nakayama H, Kitamori K, Sato I, Hirohata S, Watanabe S. SHRSP5/Dmcr rats fed a high-fat and high-cholesterol diet develop disease-induced sarcopenia as nonalcoholic steatohepatitis progresses. Ann Anat (IF: 2.7; Q1). 2023 May 18:152104. doi: 10.1016/j.aanat.2023.152104.

10.     Yamamoto S, Sato I, Fujii M, Kakimoto M, Honma K, Akiyama N, Sakai M, Fukuhama N, Kumazaki S, Hirohata S, Kitamori K, Yamori Y, Watanabe S. Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat. Acta Med Okayama (IF: 0.89; Q4). 2023 Feb;77(1):29-36. doi: 10.18926/AMO/64358.

11.      Matsuzaki M, Yokoyama M, Yoshizawa Y, Kaneko N, Naito H, Kobayashi H, Korenaga A, Sekiya S, Ikemura K, Opoku G, Hirohata S, Iwamoto S, Tanaka K, Tomita T. ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711 Molecular Psychiatry (IF: 13.44; Q1) 2023; 28, 1802–1812. https://doi.org/10.1038/s41380-023-01946-y

12.   Tanaka R, Waki I, Kamikawa S, Yamashita D, Tabita1N, Nishimura S, Higashiya S, Yamaji H,Murakami T, Kusachi S. Reproducibility of cardiopulmonary exercise testing between one after and 1–3 weeks after elective percutaneous coronary intervention.　Journal of Exercise Rehabilitation 2023;19(5):268-274

13.   Kawafuji1 S, Yamaji Y, Kayama M, Akiyama A, Miyahara M, Tomiya T, Koumoto T, Akagi A, Higashiya S, Murakami T, Kusachi S. Usefulness of three‑dimensional pulmonary vein‑left atrium image reconstructed from non‑enhanced computed tomography for atrial fbrillation ablation. The International Journal of Cardiovascular Imaging 2023 https://doi.org/10.1007/s10554-023-02943-6.

14.   Yamaji H, Kawafuji S, Sano M, Higashiya S, Murakami T, Kawamura H, Murakami M, Kamikawa S, Kusachi 

        S. Small olitary atrial fractionated electrogram zone as a novel ablation target for persistent atrial fibrillation. 

        J  Cardiovas Electroprysiol 2023；34;1130-1140.

2022

15.      Alcantara MC, Suzuki K, Acebedo AR, Kajioka D, Hirohata S, Kaisho T, Hatano Y, Yamagata K, Takahashi S, Yamada G. Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice. iScience (IF: 4.45; Q1). 2022; 25(12): 105609. doi: 10.1016/j.isci.2022.105609. eCollection 2022 Dec 22

16.      Sato I, YamamotoS, Kakimoto M, Fujii M, Honma K, Kumazaki S, Matsui M, Nakayama H, Kirihara S, Ran S, Usui S, Shinohata R, Kitamori K, Hirohata S, Watanabe S. Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism. Pharmacol Rep (IF: 3.02; Q3) 2022, 74(4): 669-683. doi: 10.1007/s43440-022-00380-1.

17.     Inagaki J, Nakano A, Hatipoglu O.F, Ooka Y, Tani Y, Miki A, Ikemura K, Opoku G, Ando R, Kodama S, Ohtsuki T, Yamaji H, Yamamoto S, Katsuyama E, Watanabe S, Hirohata S. Potential of a novel chemical compound targeting matrix metalloproteinase-13 for early osteoarthritis: an in vitro study. Int. J. Mol. Sci. (IF: 4.56; Q1) 2022, 23(5): 2681; doi: 10.3390/ijms23052681

18.      Shinohata R, Shibakura M, Arao Y, Watanabe S, Hirohata S, Usui S. A high-fat/high-cholesterol diet, but not high-cholesterol alone, increases free cholesterol and apoE-rich HDL serum levels in rats and upregulates hepatic ABCA1 expression. Biochimie (IF: 4.08; Q2) 2022, 197: 49-58. doi: 10.1016/j.biochi.2022.01.011.

19.   Sato I, Yamamoto S, Kakimoto M, Fujii M, Honma K, Kumazaki S, Matsui M, Nakayama H, Kirihara S, Ran S, Hirohata S, Watanabe S. Basic characteristics between mechanomyogram and muscle force during twitch and tetanic contractions in rat skeletal muscles. J Electromyogr Kinesiol. (IF: 2.37; Q4) 2022 Feb; 62:102627. doi: 10.1016/j.jelekin.2021.102627.

2021

20.     Bhattiprolu OF, Uctepe E, Opoku G, Wake H, Ikemura K, Ohtsuki T, Inagaki J, Gunduz M, Gunduz E, Watanabe S, Nishinaka T, Takahashi H, Hirohata S. Osteopontin Silencing Attenuates Bleomycin-induced Murine Pulmonary Fibrosis by Regulating Epithelial-mesenchymal Transition Biomedicine & Pharmacother 202; 139: 111633. doi: 10.1016/j.biopha.2021.111633

21.   Ogino N, Ikeda F, Namba S, Ohkubo S, Nishimura T, Okada H, Hirohata S, Suganuma N, Ogino K.　Plasma arginase-1 level is associated with the mental status of outpatients with chronic liver disease. Diagnostics 2021; 11(2): 317. doi: 10.3390/diagnostics11020317.

22.   Yamaji H, Higashiya S, Murakami T, Kawamura H, Murakami, M, Kamikawa S, Kusachi S. Rates of atrial flutter occurrence and cavotricuspid isthmus reconduction after prophylactic isthmus ablation performed during atrial fibrillation ablation: A clinical study, review, and comparison with previous findings. Journal of Interventional Cardiac Electrophysiology.2021：online 09 November

2020 

23.      Shinohata R, Shiga Y, Miura SI, Hirohata S, Shibakura M, Ueno-Iio T, Watanabe S, Arao Y, Usui S. Low plasma apolipoprotein E-rich high-density lipoprotein levels in patients with metabolic syndrome. Clin Chim Acta in press

24.   Yamaji H, Higashiya S, Murakami T, Hina K, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S. Efficacy of an Adjunctive Electrophysiological Test-Guided Left Atrial Posterior Wall Isolation in Persistent Atrial Fibrillation Without a Left Atrial Low Voltage Area. Circ Arrhythm Electrophysiol. 2020;13: 768-780 doi: 10.1161/CIRCEP.119.008191.

25.   Ohtsuki T, Hatipoglu OF, Asano K, Inagaki J, Nishida K, Hirohata S. Induction of CEMIP in chondrocytes by inflammatory cytokines: underlying mechanisms and potential involvement in osteoarthritis. Int J Mol Sci 2020, 21, 3140; doi: 10.3390/ijms21093140

26.   Hatipoglu OF, Miyoshi T, Yonezawa T, Kondo M, Amioka N, Yoshida M, Akagi S, Nakamura K, Hirohata S, Ito H. Deficiency of CD44 prevents thoracic aortic dissection in a murine model. Sci Rep 10, 6869 (2020)　 doi.org/10.1038/s41598-020-63824-9

27.   Yamamoto S, Sato I, Fukuhama N, Akiyama N, Sakai M, Kumazaki S, Ran S, Hirohata S, Kitamori K, Yamori Y, Watanabe S. Bile acids aggravate nonalcoholic steatohepatitis and cardiovascular disease in SHRSP5/Dmcr rat model. Exp Mol Pathol. 2020 Apr 1;114:104437. doi: 10.1016/j.yexmp.2020.104437

28.   Yamashita D, Kamikawa S, Tanaka R, Tabita N, Nishimura S, Mitsuoka, M, Higashiya S, Yamaji H, Murakami T, Hina K, Kusachi S. Correlation of the peak oxygen consumption and ventilatory aerobic threshold by cardiopulmonary exercise testing with atrial fibrillation recurrences after ablation in patients with paroxysmal atrial fibrillation. Journal of Arrhythmia. 2020;36:456–463.

2019

29.   Yamaji H, Murakami T, Hina K, Higashiya S, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S. Activated clotting time on the day of atrial fibrillation ablation for minimally interrupted and uninterrupted direct oral anticoagulation therapy: Sequential changes, differences among direct oral anticoagulants, and ablation safety outcomes. J Cardiovasc Electrophysiol. 2019 Dec;30(12):2823-2833. doi: 10.1111/jce.14260.

30.   Kumazaki S, Nakamura M, Sasaki A, Tagashira R, Maruyama N, Sato I, Yamamoto S, Ran S, Usui S, Shinohata R, Ohtsuki T, Hirohata S, Kitamori K, Mori M, Yamori Y, Watanabe S. Bile acid metabolism is an intermediary factor between non-alcoholic steatohepatitis and ischemic heart disease in SHRSP5/Dmcr rats. J Nutri Food Sci 9: 763. 2019. doi: 10.35248/2155-9600.19.9.763

31.   Yamaji H, Higashiya S, Murakami T, Hina K, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S. Effects of Oral Anticoagulants on Patients With Atrial Fibrillation Aged 90 Years and Older: Comparison Among Direct Oral Anticoagulant, Warfarin Anticoagulant, and Nonanticoagulation.  J Cardiovasc Pharmacol. 2019 Sep;74(3):246-254. doi: 10.1097/FJC.0000000000000703.

32.     Ohtsuki T, Shinaoka A, Kumagishi-Shinaoka K, Asano K, Hatipoglu OF, Inagaki J, Takahashi K, Oohashi T, Nishida K, Naruse K, Hirohata S. Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. Exp Cell Res. 2019; 383(2): 111556.  doi: 10.1016/j.yexcr.2019.111556.

33.  Amioka N, Miyoshi T, Otsuka H, Yamada D, Takaishi A, Ueeda M, Hirohata S, Ito H. Serum malondialdehyde-modified low-density lipoprotein levels on admission predict prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention. J Cardiol. 2019; 74(3): 258-266.  doi: 10.1016/j.jjcc.2019.02.012.

34.    Yamaji H, Murakami T, Hina K, Higashiya S, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S.  Adjunctive left anterior line ablation induced left atrial dysfunction and dyssynchrony in atrial fibrillation ablation. Heart Vessels. 2019 Feb; 34(2): 331-342. doi: 10.1007/s00380-018-1238-x.

2018

35.    WatanabeS, Kumazaki S, Yamamoto S, Sato I, Kitamori K, Mori M, Yamori Y, Hirohata S. Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model. Int J Exp Pathol 2018;　99(6):　282-294. doi: 10.1111/iep.12301.

36.     Ohtsuki T, Asano K, Inagaki J, Shinaoka A, Kumagishi-Shinaoka K, Cilek MZ, Hatipoglu OF, Oohashi T, Nishida K, Komatsubara I, Hirohata S. High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression.  J Orthop Res. 2018 Dec; 36(12): 3247-3255. doi: 10.1002/jor.24126.

37.     Asano K, Edamatsu M, Hatipoglu OF, Inagaki J, Ono M, Ohtsuki T, Oohashi T, Hirohata S.　Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.　 Acta Med Okayama. 2018 Jun;72(3):257-266. doi: 10.18926/AMO/56071.

38.     Yamaji H, Murakami T, Hina K, Higashiya S, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S. Differences in activated clotting time and initial heparin dosage during atrial fibrillation ablation for patients with edoxaban compared with warfarin. J Cardiovasc Electrophysiol. 2018 Jun;29(6):835-843. doi: 10.1111/jce.13483.

39.   Watanabe S, Kumazaki S, Kusunoki K, Inoue T, Maeda Y, Usui S, Shinohata R, Ohtsuki T, Hirohata S, Kusachi S, Kitamori K, Mori M, Yamori Y, Oka H. A High-Fat and High-Cholesterol Diet Induces Cardiac Fibrosis, Vascular Endothelial, and Left Ventricular Diastolic Dysfunction in SHRSP5/Dmcr Rats.  J Atheroscler Thromb.　 2018 May 1;　25(5):　439-453. 　doi: 10.5551/jat.40956.

2017

40.    Asano K, Nelson CM, Nandadasa S, Aramaki-Hattori N, Lindner DJ, Alban T, Inagaki J, Ohtsuki T, Oohashi T, Apte SS, Hirohata S.　Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis.　Sci Rep. 2017 Dec 8; 7(1): 17225. doi: 10.1038/s41598-017-17613-6.

41.   Takagi W, Miyoshi T, Doi M, Okawa K, Nosaka K, Nishibe T, Matsuo N, Hirohata S, Ito H.　Circulating adipocyte fatty acid-binding protein is a predictor of cardiovascular events in patients with stable angina undergoing percutaneous coronary intervention　BMC Cardiovasc Disord. 2017 Oct 10; 17(1):258. doi: 10.1186/s12872-017-0691-2.

42.   Hirohata S, Inagaki J, Ohtsuki T.　Diverse Functions of a Disintegrant and Metalloproteinase with Thrombospondin Motif-1. Yakugaku Zasshi. 2017; 137(7): 811-814. 

43.   Nosaka K, Miyoshi T, Iwamoto M, Kajiya M, Okawa K, Tsukuda S, Yokohama F, Sogo M, Nishibe T, Matsuo N, Hirohata S, Ito H, Doi M. Early initiation of eicosapentaenoic acid and statin treatment is associated with better clinical outcomes than statin alone in patients with acute coronary syndromes: 1-year outcomes of a randomized controlled study. Int J Cardiol. 2017 Feb 1; 228: 173-179. doi: 10.1016/j.ijcard.2016.11.105.

44.   Ikeda T, Shinohata R, Murakami M, Hina K, Kamikawa S, Hirohata S, Kusachi S, Tamura A, Usui S.  A rapid and precise method for measuring plasma apoE-rich HDL using polyethylene glycol and cation-exchange chromatography: a pilot study on the clinical significance of apoE-rich HDL measurements.  Clin Chim Acta. 2017 Feb; 465:112-118. doi: 10.1016/j.cca.2016.12.016.

45.   Yamashita D, Kamikawa S, Tanaka R, Tabita N, Nishimura S, Mitsuoka, M, Higashiya S, Yamaji H, Murakami T, Hina K, Kusachi S. Correlation of the peak oxygen consumption and ventilatory aerobic threshold by cardiopulmonary exercise testing with atrial fibrillation recurrences after ablation in patients with paroxysmal atrial fibrillation. Journal of Arrhythmia. 2020;36:456–463.

46.   Higashiya S, Yamaji H, Murakami T, Hina K, Kawamura H, Murakami M, Kamikawa S, Komatsubara I, Kusachi S.  Adjunctive interpulmonary isthmus ablation has no added effects on atrial fibrillation recurrence. Open Heart　2017;4:e000593.

2016

47.     Kumar S, Chen M, Li Y, Wong FH, Thiam CW, Hossain MZ, Poh KK, Hirohata S, Ogawa H, Angeli V, Ge R.  Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice.  Sci Rep. 2016 Aug 5; 6: 31130. doi: 10.1038/srep31130.

48.     Yamamoto K, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S, Dudhia J, Troeberg L, Strickland DK, Hirohata S, Nagase H.　MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.　Matrix Biol. 2016 Dec;　56:　57-73. doi: 10.1016/j.matbio.2016.03.007.

49.     Komatsubara I, Kondo J, Akiyama M, Takeuchi H, Nogami K, Usui S, Hirohata S, Kusachi S. Subclavian steal syndrome: a case report and review of advances in diagnostic and treatment approaches. 　Cardiovasc Revasc Med. 2016 Jan-Feb;17(1):54-8. doi: 10.1016/j.carrev.2015.11.001.

50.   Yamaji H, Murakami T, Hina K, Higashiya S, Kawamura H, Murakami M, Kamikawa S, Komtasubara I, Kusachi S. 016). Adequate Initial Heparin Dosage for Atrial Fibrillation Ablation in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants. Clin Drug Investig　2016;36:837-848.

2015

51.     Ishii H, Kamikawa S, Hirohata S, Mizutani A, Abe K, Seno M, Oohashi T, Ninomiya Y.　 Eosinophil Cationic Protein Shows Survival Effect on H9c2 Cardiac Myoblast Cells with Enhanced Phosphorylation of ERK and Akt/GSK-3β under Oxidative Stress. Acta Med Okayama. 2015 Jun;69(3):145-53.

52.     Altuntas A, Halacli SO, Cakmak O, Erden G, Akyol S, Ugurcu V, Hirohata S, Demircan K.  Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells.  Mol Med Rep. 2015 Jul;12(1):595-600. doi: 10.3892/mmr.2015.3444. 

2014

53.     Doi M, Nosaka K, Miyoshi T, Iwamoto M, Kajiya M, Okawa K, Nakayama R, Takagi W, Takeda K, Hirohata S, Ito H. Early eicosapentaenoic acid treatment after percutaneous coronary intervention reduces acute inflammatory responses and ventricular arrhythmias in patients with acute myocardial infarction: A randomized, controlled study.  Int J Cardiol. 2014 Oct 20; 176(3): 577-82. doi: 10.1016/j.ijcard.2014.08.055.

54.   Kitawaki T, Oka H, Usui S, Hirohata S, Kusachi S. New Estimation Method of Total Creatine Phosphokinase Release in Early Stage in Acute Myocardial Infarction. International Journal of Cardiovascular and Cerebrovascular Disease 2014; 2(2):18-27 doi:10.13189/ijccd.2014.020202.

55.   Demircan K, Topcu V, Takigawa T, Akyol S, Yonezawa T, Ozturk G, Ugurcu V, Hasgul R, Yigitoglu MR, Akyol O, McCulloch DR, Hirohata S. ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury. Biomed Res Int. 2014; 2014: 693746. doi: 10.1155/2014/693746.

56.   Inagaki J, Takahashi K, Ogawa H, Asano K, Hatipoglu OF, Zeynel Cilek M, Obika M, Ohtsuki T, Hofmann M, Kusachi S, Ninomiya Y, Hirohata S.  ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor. Exp Cell Res. 2014 May 1; 323(2):263-75

57.    Miyoshi T, Doi M, Usui S, Iwamoto M, Kajiya M, Takeda K, Nosaka K, Nakayama R, Okawa K, Takagi W, Nakamura K, Hirohata S, Ito H. Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease. Atherosclerosis. 2014; 233(2): 454-459.